Creatine kinase isoenzyme activity during and after an ultra-distance (200 km) run

Hee Jeong Son, Yoon Hee Lee, Jeong Hoon Chae, Chang Keun Kim
Biol Sport 2015; 32(4):357-361

It is commonly assumed that creatine kinase (CK) activity in plasma is related to a state of an inflammatory response in 24-48 h and also has shown biphasic patterns after marathon run. No information available on the CPK isoenzymes after ultra-marathon run. The purpose of the present study is to examine the CK isoenzymes after a 200 km ultra-marathon run and during the subsequent recovery. Blood samples were obtained during registration 1–2 h before the 200-km race and during the race at 100 km, 150 km and at the end of 200 km, as well as after a 24 h period of recovery. Thirty-two male ultra-distance runners were participated in the study. Serum CPK showed a marked increase throughout the race and 24 h recovery (p<0.001). Serum CPK during the race occurs mostly in the CK-MM isoform and only minutely in the CK-MB and unchanged in CK-BB isoforms. Hs-CRP, estradiol, AST, and ALT increased significantly from the pre-race value at 100 km and a further increase took place by the end of the 200 km run. The results of our study demonstrate a different release pattern of creatine kinase after an ultra-distance (200 km) run from the studies of marathon run and intense eccentric exercise, and changes in several biomarkers, indicative of muscle damage during the race, were much more pronounced during the latter half (100–200 km) of the race. However, the increases in plasma level of muscle enzymes may not only reflect structural damage, but also its rate of clearance.

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