تمرین شنا و مکمل diselenide بر سایتوکاین ها التهابی و ضد التهابی متاثر از سالمندی، تاثیر دارد (مقاله لاتین)

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Marlon R. Leite a, José L. Cechella a, Anderson C. Mantovani a, Marta M.M.F. Duarte b,
Cristina W. Nogueira a, Gilson Zeni a,⇑
a Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria,
Santa Maria CEP 97105-900, Rio Grande do Sul, Brazil
b Departamento de Ciências da Saúde, Universidade Luterana do Brazil, Santa Maria, Rio Grande do Sul, Brazil

The increase in the inflammatory process is one of the main factors that contribute to aging. The aim of this study was to investigate the effects of a diphenyl diselenide (PhSe)₂-supplemented diet (1 p.p.m., 4 weeks) and swimming exercise (3% of body weight, 20 min per day, 4 weeks) on the serum levels of cytokines in Wistar rats of different ages. The results demonstrated an increase in the levels of pro-inflammatory cytokines (IL-1β, IL-6, TNFα and INFγ) and a decrease in the levels of IL-10, an anti-inflammatory cytokine, with age. In middle-age rats, the swimming exercise and (PhSe)₂-supplemented diet decreased serum levels of pro-inflammatory cytokines and increased the levels of IL-10. By contrast, in old rats the swimming exercise protocol increased the serum levels of pro-inflammatory cytokines and decreased the levels IL-10. Diet supplemented with (PhSe)₂ did not alter the serum levels of cytokines in old rats. Middle-age and old rats subjected to swimming exercise and supplemented with (PhSe)₂ in the diet had a decrease in the serum levels of pro-inflammatory cytokines and an increase in the levels of IL-10. This study demonstrated that swimming exercise and (PhSe)₂-supplemented diet affect the serum levels of pro- and anti-inflammatory cytokines differently depending on the age of rats. (PhSe)₂ supplemented in the diet had an anti-inflammatory effect, similar to that of induced by swimming exercise, in middle-age rats and reversed the pro-inflammatory effects of swimming exercise in old rats